Product ID:CYTOXAN FOR INJECTION
MSDS Date:03/01/1990
FSC:6505
NIIN:01-156-1970
MSDS Number: CBSHJ

Emergency Phone: 812-429-5678

Info Phone: 812-429-5678

Cage: BRIST

Telephone: 908-519-2385

Cage: 97374

U058

CAS: 6055-19-2

RTECS: RP5950000

Fraction By Weight: 70% %

NON-HAZARDOUS INGREDIENTS

Fraction By Weight: 30% %

LD50 LC50 Mixture:ORAL LD50 (RAT): 94 MG/KG
Routes of Entry: Inhalation:NO Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:YES OSHA:NO
Health Hazards Acute and Chronic:INGESTION: CYTOTOXIC AGENT. IMPORTANT
DOSE-DEPENDENT EFFECTS INCLUDE BONE MARROW SUPPRESSION,
GASTROURINARY, LUNG AND CARDIAC TOXICITY. ABSORPTION FROM SKIN
AFTER TOPICAL APPLICATION. POSSIBLE RASH UP ON CONTACT. MAY CAUSE
CONJUNCTIVITIS UPON EYE CONTACT. POTENTIAL CARCINOGEN.
Explanation of Carcinogenicity:ACCORDING TO BRISTOL- MEYERS,
CYCLOPHOSPHAMIDE IARC REVIEW: HUMAN POSITIVE
Effects of Overexposure:BONE MARROW SUPPRESSION, GASTROURINARY, LUNG
DAMAGE, CARDIAC EFFECTS, SKIN RASH, EYE IRRITATION, CONJUNCTIVITIS.
Medical Cond Aggravated by Exposure:NONE SPECIFIED BY MANUFACTURER.

First Aid:EYE: WASH EYE WITH A COPIOUS AMOUNT OF WATER FOR 15 MINUTES
AND THEN IMMEDIATLEY SEEK MEDICAL ATTENTION. SKIN: WASH AFFECTED
AREA IMMEDIATELY WITH SOAP AND WATER. INGESTION: SEEK PROFESSIONSL
MEDICAL ATTENTION IF APPROPRIATE. INHALATION: SEEK PROFESSIONAL
MEDICAL ATTENTION IF APPROPRIATE.

Flash Point:NONFLAMMABLE
Lower Limits:NOT GIVEN
Upper Limits:NOT GIVEN
Extinguishing Media:WATER, CO2, FOAM, DRY CHEMICAL.
Fire Fighting Procedures:FIRE FIGHTERS SHOULD WEAR SELF CONTAINED
BREATHING APPARATUS AND FULL PROTECTIVE GEAR.
Unusual Fire/Explosion Hazard:WHEN HEATED TO DECOMPOSITION, HEAT AND
FUMES MAY BE RELEASED.

Spill Release Procedures:ISOLATE AREA & WEAR SUITABLE PROTECTIVE
EQUIPMENT. COLLECT W/PAPER TOWELING & MOISTEN PRIOR TO PICK UP TO
MINIMIZE DUST GENERATION. CLEAN AREA USING SEVERAL WASHES
W/DETERGENT & WATER. TREAT PRODUCT/C ONTAMINATED MATERIALS AS
HAZARDOUS WASTE.
Neutralizing Agent:NONE SPECIFIED BY MANUFACTURER.

Handling and Storage Precautions:STORAGE AT OR BELOW 77F.
Other Precautions:AVOID INHALATION/INGESTION/SKIN CONTACT.
DECONTAMINATE PROTECTIVE EQUIPMENT AFTER USE. PROVIDE APPROPRIATE
BONDING & GROUNDING PROTECTION TO CONTROL STATIC CHARGES.

Respiratory Protection:WEAR A NIOSH APPROVED DUST RESPIRATOR W/HIGH
EFFICIENCY DUST FILTER/POWERED AIR-PURIFYING RESPIRATOR WHEN
ENGINEERING CONTROLS AREN'T SUFFICIENT TO CONTROL EXPOSURE. WEAR
SELF CONTAINED BREATHING APPA RATUS IN EMERGENCIES.
Ventilation:LOCAL MECHANICAL EXHAUST: EXPLOSION PROOF. BIOLOGICAL
CABINET SHOULD BE USED FOR PREPARATION OF THIS DRUG.
Protective Gloves:DISPOSABLE SURGICAL LATEX
Eye Protection:CHEMICAL SAFETY GOGGLES
Other Protective Equipment:IMPERVIOUS DISPOSABLE COVERALLS W/CLOSED
FRONT, LONG SLEEVES & ELASTIC CUFFS, BOOTS, EXPLOSION PROOF
EQUIPMENT.
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
REUSE. WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
FEDERAL LAW PROHIBITS DISPENSING WITHOUT PRESCRIPTION. SEE PACKAGE
INSERT FOR RECOMMENDED MEDICAL USE.

HCC:N1
Boiling Pt:B.P. Text:NOT GIVEN
Melt/Freeze Pt:M.P/F.P Text:106F,41C
Vapor Pres:NOT GIVEN
Vapor Density:NOT GIVEN
Spec Gravity:NOT GIVEN
Evaporation Rate & Reference:NOT GIVEN
Solubility in Water:APPRECIABLE
Appearance and Odor:WHITE POWDER

Stability Indicator/Materials to Avoid:YES
NONE SPECIFIED BY MANUFACTURER.
Stability Condition to Avoid:TEMPS >86F, IGNITION SOURCES.
Hazardous Decomposition Products:CO, CO2, CHLORINE, HYDROGEN CHLORIDE,
OXIDES OF NITROGEN & PHOSPHOROUS, PHOSPHINE.
Conditions to Avoid Polymerization:WILL NOT OCCUR AT NORMAL
TEMPERATURES. MAY OCCUR AT TEMPERATURES ABOVE 120F.

Waste Disposal Methods:UNUSED PRODUCT IS HAZARDOUS WASTE (U058); LAND
DISPOSAL IS PROHIBITED. TREAT CONTAMINATED MATERIALS AS HAZARDOUS
WASTE. INCINERATION IS RECOMMENDED.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.